Questions and Answers About Taking Estradiol Vaginal Cream

Have you been experiencing persistent vaginal dryness, burning, and itching? These could be symptoms of menopause or other hormonal changes. Estradiol vaginal cream is an effective solution to help relieve these unpleasant side effects caused by diminished levels of estrogen hormones. Read on to learn more about this hormone supplement therapy and its numerous benefits for women struggling with uncomfortable symptoms due to imbalanced hormones.


What is Estradiol Vaginal Cream?

Estradiol vaginal cream is a hormone therapy that reduces menopausal symptoms like hot flashes, night sweats, and dryness. It is also used to increase sexual pleasure. It comes in a convenient applicator tube with pre-measured doses that can be quickly and easily inserted into the vagina. The cream replaces the estrogen your body no longer produces due to menopause. By restoring natural hormones, estradiol vaginal cream can help relieve symptoms and restore sexual pleasure.

What is the importance of using estradiol as prescribed by the doctor?

It is crucial to use estradiol vaginal cream as your doctor prescribes to minimize the risk of side effects and ensure optimal results. When used correctly, estradiol can help reduce symptoms of menopause, such as hot flashes and night sweats. Additionally, it can help relieve vaginal dryness and discomfort caused by low estrogen levels. If you do not follow your doctor’s instructions exactly or make any sudden changes to your dosage, you may experience adverse side effects or decreased medication effectiveness. Therefore, it is essential always to follow the advice given by your doctor when using estradiol vaginal cream.

How long should it be used without a break?

DHEA vaginal cream should not be used for more than four weeks without a break of at least two weeks. It is essential to follow the dosage instructions provided by your doctor and not exceed the recommended dose. Talk with your doctor if you have questions or concerns about using estradiol vaginal cream safely and effectively.

Are there any possible risks associated with using estradiol vaginal cream?

Estradiol vaginal cream, like any other medication, has the potential to cause unwanted side effects. These can include skin irritation, breast tenderness, headaches, and mood changes. Other possible risks include an increased risk of blood clots, stroke, heart attack, or breast cancer, particularly for those at higher risk due to age or prior medical history. Before beginning treatment, it is important to talk with your doctor about any possible risks associated with using estradiol vaginal cream.

Is there anything else you should know while using estradiol vaginal cream?

Yes, it is essential to remember that estradiol vaginal cream should be used as prescribed by your doctor. Only use more or less of the cream than recommended, and only adjust your dosage after first speaking with your doctor. Additionally, consult with a medical professional before using the cream, as it is possible to experience withdrawal symptoms when discontinuing treatment.

List of interactions between estradiol and other medications.

Below is a list of drugs that may interact with estradiol vaginal cream:

  • Estrogens, medications containing progesterone, or any other hormone replacement therapy
  • Antibiotics such as rifampin, ampicillin, and erythromycin
  • Corticosteroids like prednisone or methylprednisolone
  • Antifungal medications such as ketoconazole or itraconazole
  • Antiplatelet agents like clopidogrel or ticagrelor
  • Selective serotonin reuptake inhibitors (SSRIs) for depression
  • Birth control pills
  • Grapefruit juice
  • St. John’s wort.


At Harbor Compounding Pharmacy, we understand that women’s health needs are unique and vital. That’s why we also offer custom compounded estradiol vaginal cream. Our knowledgeable and friendly pharmacists are here to help answer any questions and ensure that you receive the proper care and guidance when using this medication. We want to help you feel your best and improve your quality of life. Trust us to provide you with the personalized attention and care you deserve.